Common side effects of delta sleep-inducing peptide (DSIP)
Share
Common side effects of delta sleep-inducing peptide (DSIP) include alterations in heart rate, heart rate variability, and electroencephalogram (EEG) patterns. These effects have been observed in clinical studies and are important considerations when evaluating the safety profile of DSIP.
1. Cardiovascular Effects: DSIP has been shown to significantly increase heart rate and decrease heart rate variability (HRV). In a study involving female patients undergoing isoflurane anesthesia, DSIP administration resulted in increased heart rate and decreased HRV, suggesting a reduction in parasympathetic tone. These cardiovascular changes are important to monitor, especially in patients with pre-existing cardiovascular conditions.[1]
2. EEG Alterations: DSIP can significantly alter EEG patterns. The same study noted that DSIP administration led to a paradoxical reduction in delta rhythm, which is typically associated with deep sleep, and an increase in bispectral index (BIS), indicating a lighter depth of anesthesia. Additionally, DSIP altered the bilateral symmetry of the EEG, which could have implications for its use in clinical settings where EEG monitoring is critical.[1]
3. Sleep Quality and Efficiency: In a double-blind study involving chronic insomniac patients, DSIP was found to improve objective sleep quality by increasing sleep efficiency and reducing sleep latency. However, the subjective measures of sleep quality and tiredness did not show significant changes, indicating that the perceived benefits might not align with the objective improvements. This discrepancy suggests that while DSIP may enhance certain aspects of sleep architecture, its overall impact on perceived sleep quality may be limited.[2]
4. Stress and Mitochondrial Function: DSIP has been studied for its effects on stress and mitochondrial function. It has been shown to enhance the efficiency of oxidative phosphorylation and protect against hypoxia-induced mitochondrial dysfunction in rat brain mitochondria. While these findings are promising, they are primarily based on animal studies, and the translation of these effects to human subjects requires further investigation.[3]
In summary, the common side effects of DSIP include increased heart rate, decreased heart rate variability, and alterations in EEG patterns, particularly a reduction in delta rhythm and changes in EEG symmetry. These effects highlight the need for careful monitoring of cardiovascular and neurological parameters when using DSIP, especially in clinical settings. While DSIP shows potential benefits in improving sleep efficiency and protecting against stress-induced mitochondrial dysfunction, its overall impact on subjective sleep quality and its safety profile in humans require further research.
1. Delta Sleep-Inducing Peptide Alters Bispectral Index, the Electroencephalogram and Heart Rate Variability When Used as an Adjunct to Isoflurane Anaesthesia.
Pomfrett CJ, Dolling S, Anders NR, et al. European Journal of Anaesthesiology. 2009;26(2):128-34. doi:10.1097/EJA.0b013e32831c8644.
2. Effects of Delta Sleep-Inducing Peptide on Sleep of Chronic Insomniac Patients. A Double-Blind Study. Bes F, Hofman W, Schuur J, Van Boxtel C. Neuropsychobiology. 1992;26(4):193-7. doi:10.1159/000118919.
3. Delta Sleep Inducing Peptide (DSIP): Effect on Respiration Activity in Rat Brain Mitochondria and Stress Protective Potency Under Experimental Hypoxia.
Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II. Peptides. 2003;24(2):307-11. doi:10.1016/s0196-9781(03)00040-8.